Methimazole was more effective than propylthiouracil in the induction of euthyroidism. 在促进诱导甲状腺功能正常方面,甲基硫氧咪唑优于丙基硫氧嘧啶。
Conclusion Methimazole is the first choice for the treatment of hyperthyroidism disease. 结论门诊治疗甲状腺功能亢进症,甲巯咪唑为首选。
Thionamides Class of anti-thyroid drugs (such as carbimazole, methimazole, and propylthiouracil) that inhibit thyroid hormone synthesis by interfering with organification. 硫酰胺类抗甲状腺药物的种类(如卡比马唑、甲巯咪唑和丙基硫氧嘧啶),此类药物通过干扰有机化抑制甲状腺激素的合成。
The incidence of malformed infants whose mothers received methimazole (MMI; 41.7%, 5/12)was significantly higher than that of mothers treated with propylthiouracil (PTU)(3.6%,1/28) and without ATDs(1.6%,1/61) , respectively ( P其母孕早期服用丙基硫氧嘧啶的28例新生儿中;合并新生儿先天畸形1例;先天畸形发生率为3.;6%25; 其母孕早期未服用ATDs的61例新生儿中;合并新生儿先天畸形1例;先天畸形发生率为1