Fig.5 The Linear and superhelix DNA of PBS plasmid,L:linear DNA,SU:superhelix DNA. 图5PBS质粒的线状及超螺旋DNA结构,SU:为DNA的超螺旋结构,L:为DNA的线状结构。
After absorption, prulifloxacin is metabolised by esterases to ulifloxacin, which inhibits the formation of superhelix, cell division and reproduction by interfering the DNA toposomerase. 本品为前体药,其活性代谢产物通过阻碍DNA拓扑异构酶使细菌DNA无法形成超螺旋,导致细菌细胞无法分裂繁殖。
specific linking difference(superhelix density) 比连接差